Outlook data file cannot be accessed, Error 0x8004010F can be caused due to profile corruption, PST corruption, PST file corruption, relocation of the PST file, etc.

Instead, you have to visit Settings > General > Outlook Data Files. Once you know the corrupted file's location, we can launch an executable file, ScanPST, in the Microsoft Office folder.

Certain add-ins can prevent Outlook from closing out the data file. Sometimes simply disabling and then re-enabling an add-in can resolve the problem, but depending on the extension you may need ...