CHICAGO -- A bumetanide nasal spray in development for heart failure was well-tolerated and showed reliable rates of absorption compared with oral and intravenous delivery in a phase I trial of ...

A new nasal spray form of the medication bumetanide may reduce the tissue swelling caused by heart failure as effectively as ...

Give as single spray intranasally into one nostril. May give additional doses (using a new nasal spray) every 2–3mins in alternate nostrils if unresponsive or relapses into respiratory depression.

Drug Pharmacologic Class Proposed Indication Status Cardiovascular Disease Bumetanide nasal spray (RSQ-777; Corstasis Therapeutics) Loop diuretic Treatment of edema associated with congestive heart… ...