Dr. Timothy Palzkill, professor of Pharmacology and Chemical Biology and Molecular Virology and Microbiology, and his research team have been studying mechanisms of resistance to the beta-lactam ...

which can make organisms resistant to almost all beta-lactam antibiotics. MBL-producing Gram-negative bacteria are among the most challenging infections to control, are on the rise globally ...

The appropriateness of combination therapy for infections caused by gram-negative ... resistant bacteria or fungi. There are no clinical data that suggest that the combination of a β-lactam ...

Bacterial cells can also make enzymes that chemically inactivate antibiotics; these include beta-lactamase ... when it comes to antibiotic resistance, gram-negative bacteria have an edge thanks ...

Enzyme-catalysed antibiotic degradation, or modification or degradation of antibiotics or their targets, is one of the major mechanisms of antibiotic resistance. Plasmid borne genes encoding modifying ...

an extended-spectrum beta-lactamase inhibitor that is in early-stage clinical testing in both intravenous and oral combinations for infections caused by drug-resistant Gram-negative bacteria.

DURHAM, N.C – A scientific journey decades in the making at Duke University has found a new antibiotic strategy to defeat gram-negative bacteria ... low rates of spontaneous resistance mutations in ...