The discovery of the Bcl-2 protein family, as well as p53 and its involvement in regulating apoptosis, and the CD95 (also known as FAS or APO1) pathway, led to an understanding of the molecular ...

Figure 2: Inhibition of caspase 3, apoptosis (caspase ... distinct cellular stress pathways and signal that a stress has occurred through interactions with other BCL-2 family members.

ABT199/venetoclax, an inhibitor of the pro-survival BCL-2 protein, has improved AML treatment ... suggests potent activation of apoptosis by this two-drug combination; increased levels of γ ...