Scientists have discovered a brain circuit that gives pain its emotional sting, explaining why some hurts linger as suffering ...

Pain is more than a physical signal — it also carries emotional weight that shapes our response and memory of discomfort.

Specifically, we discovered the mechanism of this pain we call 'sng’.” The discovery of the new pain pathway is described by the team as ‘a paradigm-shifting discovery that has fundamentally changed ...

Crucially, they found a new and distinct separate physiological pathway for this chronic type of pain, which means it can now be a target for future therapies. The work is published in the journal ...

There are two main mechanisms of pain hypersensitivity: peripheral sensitization and central sensitization. Peripheral sensitization is associated with inflammation and tissue damage.

In an established rat model of inflammatory pain, where both males and females display severe pain in response to light touch (tactile allodynia), the scientists of the new study showed a pathway ...

Descartes gave a colorful description of the mechanism of pain in the 17th Century: "Particles" of fire set in motion a spot on the skin of the foot, and by means of a "delicate thread" they open a ...

11/23/2015 | New research on a toxin released by the body in response to spinal cord injuries could point to a new route for treating pain in people with such injuries, according to Riyi Shi, ...

New life for a cancer drug that reprograms pain pathways to treat chronic pain ... Dr. Michele Yeo, worked with Liedtke for more than a decade to elucidate basic regulation of the Kcc2 gene.

In a groundbreaking discovery, chronic pain has been shown to be physiologically different from acute pain and now scientists have the roadmap for how to target it. Researchers from the University of ...

Riyi Shi (Photo/Andrew Hancock) 11/23/2015 | New research on a toxin released by the body in response to spinal cord injuries could point to a new route for treating pain in people with such injuries, ...