How did Aβ boost the urea cycle? Aβ-treated cells accumulated aspartate and ammonia, both of which feed into the cycle. Inhibiting autophagy dropped the amount of these metabolites back to nearly ...

Urea cycle disorders ... (mitochondrial aspartate/glutamate carrier deficiency-CITR). UCDs are inherited as autosomal recessive traits, except for OTC deficiency, which is X-linked.

By identifying the critical role the urea cycle plays in its development, his findings could pave the way for new medications to treat this currently incurable disease. advertisement.