These animal models have illuminated genetic mutations and developmental problems leading to conditions such as neural tube defects, including spina bifida, and congenital heart defects, improving ...

In 2020, heart failure affected about 6.5 million people in the U.S. and 23 million around the world. Despite recent advances, the five-year survival rate remains approximately 50%, indicating an ...

Following the positive in vitro data, the investigators evaluated saracatinib in animal models to see if it could stop, slow, or reverse inflammation prompted by ASCVD.

The heart may be much more than an organ simply ensuring blood circulation. A study has highlighted the presence of a complex ...

However, until now there has been no animal model that replicates sarcoidosis in the heart. Cardiac sarcoidosis in particular is often very difficult to diagnose and treat, which is why a model ...

The story “There is no replacement (yet) for animal models in medical research,” by Carole LaBonne The response. While I started my career obtaining a DPhil in biochemistry from Oxford ...

First-ever mini-Heart models will be created from hypoplastic left heart syndrome (HLHS) patient stem cells, enabling ...

Current models fall short: animal hearts differ significantly from human hearts, and flat (2D) cultures of patient cells or a simpler conventional heart-on-a-chip cannot reproduce the 3D ...