Much like the meme’s own filmic origin, the Willem Dafoe Looking Up memes will often feel a bit obscure, using niche inside jokes, and specific references that not all wider audiences might ...

This is a reference to the meme that originated from the 2018 biopic At Eternity’s Gate, in which Willem Dafoe (interpreting Vincent van Gogh) has an anxious expression as he looks at the sky.

Willem Dafoe Makes Surprise Cameo in One Piece One Piece Episode 1133 sees Kuma fighting back against the Marines, and unfortunately having to leave his home in order to keep trouble away from them.