More than 1,000 cases of alkaptonuria have been reported in the medical literature. Individuals from any group can potentially develop the disease, regardless of their sex, race or other factors.

Nitisinone reduced HGA levels and improved symptoms in patients with alkaptonuria. The Food and Drug Administration (FDA) has approved Harliku ™ (nitisinone) for the reduction of urine ...

Alkaptonuria is a rare, autosomal recessive metabolic disorder arising from the deficiency of the enzyme homogentisate 1,2-dioxygenase, which disrupts the normal degradation of tyrosine.

Alkaptonuria is an ultra-rare hereditary disorder of tyrosine and phenylalanine catabolism, and is commonly known as black urine disease due to the noticeable buildup of HGA. A slow-progressing ...

Alkaptonuria is a rare, autosomal recessive disorder caused by deficiency of an enzyme called homogentisate 1,2-dioxygenase. As an infant, the only symptom is urine that turns black upon standing.

INDIANAPOLIS — Researchers from Indiana University School of Medicine diagnosed a Sumatran orangutan at the Indianapolis Zoo with a rare genetic disease. Mila, a 6-year-old orangutan who was born at ...

When you buy through links on our articles, Future and its syndication partners may earn a commission. Symptoms: One of the earliest signs that someone has alkaptonuria is dark stains in their ...

INDIANAPOLIS — Researchers from Indiana University School of Medicine diagnosed a Sumatran orangutan at the Indianapolis Zoo with a rare genetic disease. Mila, a 6-year-old orangutan who was ...

INDIANAPOLIS — Researchers from Indiana University School of Medicine diagnosed a Sumatran orangutan at the Indianapolis Zoo with a rare genetic disease. Mila, a 6-year-old orangutan who was ...