Inflammation is closely linked to thrombosis, and platelets are critical mediators in this process. ATP and ADP signaling plays an essential role during platelet activation . ADP ...

Adenosine diphosphate (ADP) or adenosine triphosphate (ATP)-containing important biological molecules can modify macromolecules like proteins and nucleic acids to alter their function in the cell.

Once ATP has released energy, it becomes ADP (adenosine diphosphate), which is a low energy molecule. ADP can be recharged back into ATP by adding a phosphate. This requires energy.

Previously we demonstrated that ATP released from LPS-activated microglia induced IL-10 expression in a process involving P2 receptors, in an autocrine fashion. Therefore, in the present study we ...