In general, efflux is the most expedient mechanism for bacteria to deal with excess metal ions. Recent results have identified analogous proteins that mediate the efflux of both Fe( II ) 23 and Mn ...

The global rise of antibiotic resistance and the paucity of novel antimicrobial compounds in the pipeline have revived interest in the use of metals as antimicrobial agents. Here, Lemire, Harrison ...

Using nuclear magnetic resonance (NMR) spectroscopy, the researchers were able to determine how the structure of this protein changes as a drug-like molecule moves through it.

The general approach of targeting stresses already applied by natural defense mechanisms could be a promising new way to treat infections. "We badly need new approaches to fight bacteria," said Singh.

Biofilms are conglomerates of bacteria and other organisms, which are feared in medicine as well as other areas because they can contain pathogens and are highly resistant to treatment. Chemists ...