Cell culture plays an important role in a wide range of biological research, from modelling diseases, to testing drug toxicity, to manufacturing vaccines. Traditionally, cultures have been planar, ...

We designed a rhesus macaque 2D choroid plexus epithelial cell culture, as well as a modified 3D cell culture model, in order to study activation, diffusion, and migration through the choroid plexus.

In 2D cell culture, the monolayer and the microenvironment do not imitate the in vivo conditions. The data accumulated using 2D models do not offer a clear understanding of the research ...

Discover how 3D biology, automation, and AI are revolutionizing drug discovery, improving predictive accuracy, and ...

The classically preferred model is a static dish culture system which mainly generates adherent two-dimensional (2D) cell monolayers. Still, such culture systems do not reflect the situation in ...

Learn about our Editorial Policies. Research and drug discovery are undergoing a transformation, driven by the rise of 3D cell culture models that better replicate human biology. Unlike traditional 2D ...

Various types of 3D cell culture model systems are currently available and being explored ... exhibits the ability to overcome many of the shortcomings of traditional 2D cell cultures. In implementing ...

Assay Drug Dev Technol. 2014;12(4):207-218. 4. Fontoura JC, et al. Comparison of 2D and 3D cell culture models for cell growth, gene expression and drug resistance. Mater Sci Eng C. 2020;107:110264. 5 ...

As an example, cells grown on two-dimensional (2D) hard plastic or glass substrates ... The favorable environment created by the 3D culture model also allows for longer-term dosing experiments ...