Quaid's leading role in Novocaine feels like a natural continuation of these genre-bent everymen. He plays Nathan Caine, a mild-mannered assistant bank manager who has congenital insensitivity to pain with anhidrosis (CIPA), a genetic disorder that impacts his nervous system to the point that he can't feel pain or temperature.

Jack Quaid stars as a man whose rare condition—he can’t feel pain—turns into something of a superpower when he goes on a bloody mission to rescue the girl of his dreams.